2023
YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations. ublished: 05 February 2023, Vol 13, Issue 2, e1190.
MesoTIRF: A prism-based Total Internal Reflection Fluorescence illuminator for high resolution, high contrast imaging of large cell populations. We are collaborators on this manuscript.
2022
The Hippo pathway drives the cellular response to hydrostatic pressure. Park J, Jia S, Salter D, Bagnaninchi P and Hansen CG. EMBO J, (2022)e108719.
Collaborative paper with the Ponting lab on a new TEAD binding protein is now out in Bioinformatics Advances. In silico analysis with great perspectives, congratulations Luis and Siyang! PERCC1, a new member of the YAP/TAZ/FAM181 transcriptional co-regulator family.
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer (Review). Cunningham R and Hansen CG. Clin Sci (Lond) (2022) 136 (3): 197–222.
Hippo-Yap/Taz signalling in zebrafish regeneration. (Review). Riley S, Feng Y and Hansen CG. PDF npj Regenerative Medicine. 7, Article number: 9 (2022).
Label2label: Training a neural network to selectively restore cellular structures in fluorescence microscopy. Lisa Sophie Kölln*Omar SalemJessica ValliCarsten Gram Hansen^Gail McConnell^. J Cell Sci jcs.258994.
2021
Collaborative study accepted in Nature Cancer. Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms. Also on the cover!
Collaborative study accepted in Science Immunology. The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair
Cellular feedback dynamics and multilevel regulation driven by the hippo pathway Park J and Hansen CG. Biochem Soc Trans (2021) BST20200253 (Review).
Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions. Utsa Karmakar, Julia Y. Chu, Kruthika Sundaram, Anne L. Astier, Hannah Garside, Carsten G. Hansen, Ian Dransfield & Sonja Vermeren. Cell Death & Disease.
2020
Listeria monocytogenes Exploits Host Caveolin for Cell-to-Cell Spreading.
The Hippo Pathway, YAP/TAZ, and the Plasma Membrane. Rausch V and Hansen CG. (Review) DOI:https://doi.org/10.1016/j.tcb.2019.10.005. Trends in Cell Biology. Selected as best of trends in cell biology 2020
2019
Disease and the Hippo Pathway. Hansen CG. (Editorial) on the completed Special Issue in Cells.
The Hippo Pathway in Prostate Cancer. Salem O and Hansen CG. (Review) 2019 Apr 23;8(4). pii: E370. doi: 10.3390/cells8040370. Cells.
The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Rausch V, Bostrom JR, Park J, Bravo IR, Feng Y, Hay DC, Link BA, Hansen CG. Volume 29, Issue 2, 21 January 2019, Pages 242-255.e6. Current Biology.
Immunofluorescence Study of Endogenous YAP in Mammalian Cells. (Book Chapter) Rausch V and Hansen CG. 2019;1893:97-106. doi: 10.1007/978-1-4939-8910-2_8. Methods Mol Biol.
2017
EHD proteins cooperate to generate caveolar clusters and to maintain caveolae during repeated mechanical stress. Ivana, Y., Howard, G., chadwick, J., Mendoza, C., Hansen, C., Nichols, B. J. & Shvets, E. 9 Oct 2017 In : Current Biology.
2015
The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Hansen, C. G., Ng, Y. L. D., Lam, W-L. M., Plouffe, S. W. & Guan, K-L. Dec 2015 . 25, 12, p. 1299-313 15. Cell Research .
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J-S., Lu, W., Lu, S., Flores, F., Yu, F-X., Halder, G. & Guan, K-L. 5 Oct 2015, 6, p. 8357 Nature Communications.
YAP and TAZ: a nexus for Hippo signaling and beyond (review) Hansen, C. G.^, Moroishi, T.^ & Guan, K-L. Sep 2015 25, 9, p. 499-513 15. Trends In Cell Biology.
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Mo, J-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D-S. & Guan, K-L. Apr 2015 In : 17, 4, p. 500-10 11 p. Nature Cell Biology.
The emerging roles of YAP and TAZ in cancer. (review) Moroishi, T^., Hansen, C. G^. & Guan, K-L. Feb 2015 In : 15, 2, p. 73-9 7 p. Nature Reviews Cancer.
2014
Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. Liu, L., Hansen, C. G., Honeyman, B. J., Nichols, B. J. & Pilch, P. F. 2014 In : PLoS One. 9, 7, p. e102935.
2013
Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Hansen, C. G., Shvets, E., Howard, G., Riento, K. & Nichols, B. J. 2013 In : Nature Communications. 4, p. 1831.
2011
Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. Hansen, C. G., Howard, G. & Nichols, B. J. 15 Aug 2011 In : Journal of Cell Science. 124, Pt 16, p. 2777-85 9 p.
2010
Exploring the caves: cavins, caveolins and caveolae. Hansen, C. G. & Nichols, B. J. Apr 2010 In : Trends In Cell Biology. 20, 4, p. 177-86 10 p.
2009
SDPR induces membrane curvature and functions in the formation of caveolae. Hansen, C. G., Bright, N. A., Howard, G. & Nichols, B. J. Jul 2009 In : Nature Cell Biology. 11, 7, p. 807-14 8 p.
Molecular mechanisms of clathrin-independent endocytosis. Hansen, C. G. & Nichols, B. J. 1 Jun 2009 In : Journal of Cell Science. 122, Pt 11, p. 1713-21 9 p.
2008
Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation. Celik, L., Sinning, S., Severinsen, K., Hansen, C. G., Møller, M. S., Bols, M., Wiborg, O. & Schiøtt, B. 26 Mar 2008 In : Journal of the American Chemical Society. 130, 12, p. 3853-65 13 p.
2006
Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. Neubauer, H. A., Hansen, C. G. & Wiborg, O. Apr 2006 In : Molecular Pharmacology. 69, 4, p. 1242-50 9 p.
Gram Hansen Lab 